SCI Journal Article Index
An association between periostin levels with the severity and chronicity of atopic dermatitis in children
Myongsoon Sung, Kyung Suk Lee, Eun Gyo Ha, Seung Jin Lee, Mi Ae Kim, Seung Won Lee, Hye Mi Jee, Youn Ho Shin, Young Ho Jung, Man Yong Han
Background: Serum periostin might be a biomarker of the pathogenesis of T helper 2-type allergic diseases. The aim of this study is to investigate the relationship between serum periostin levels and the severity and chronicity of atopic dermatitis (AD) in children.
Methods: This population-based study examined 4,076 children from aged 4 to 13 years between June 2015 and July 2015. Of the 4,076 children, 196 including 137 with a history of AD in the AD group and 59 without allergic diseases history in the healthy control (HC) group were included for the final analysis.
Results: Serum periostin levels were higher in the AD group than in the HC group (P < 0.001) and were found to be positively associated with SCORAD score (Spearman's rho [r] = 0.24, P = 0.001). Children with AD onset time < 2 years had significantly higher periostin levels (P = 0.030) compared to those with AD onset time ≥ 2 years. The total eosinophil (P = 0.189) and IgE levels (P = 0.140) were comparable between children with AD onset time < 2 years and those with AD onset time ≥ 2 years. After adjustment for age, gender, and parental allergic history, serum periostin level (OR 1.03, 95% CI 1.00 - 1.06, P = 0.046) contributed to the development of AD in children with AD onset time < 2 years.
Conclusions: Serum periostin level may play a role in the severity and chronicity of AD in children.
- PMID: 28631851