SCI Journal Article Index
Ginsenoside Rg5 prevents apoptosis by modulating HO-1/Nrf2 signaling and alters the expression of cognitive impairment-associated genes in thermal stress-exposed HT22 cells
Seo-Yun Choi, Kui-Jin Kim, Ji-Hyeon Song, Boo-Yong Lee
Our results suggested that thermal stress can lead to activation of hippocampal cell damage and reduction of memory-associated molecules in HT22 cells. These findings also provide a part of molecular rationale for the role of ginsenoside Rg5 as a potent cognitive impairment preventive compound in blocking the initiation of hippocampal damage.